The antiapoptotic protein BCL-2 is selectively and orally bioavailability inhibited by the small molecule Venetoclax. It has been shown that overexpression of BCL-2 in CLL cells mediates tumor cell survival and has been linked to chemotherapeutic resistance. By directly binding to the BCL-2 protein and displacing pro-apoptotic proteins like BIM, causing mitochondrial outer membrane permeabilization and activating caspases, venetoclax aids in the restoration of the apoptotic process. Venetoclax has demonstrated cytotoxic activity in tumor cells overexpressing BCL-2 in nonclinical studies.
Venetoclax can be used to treat adult patients with small lymphocytic lymphoma (SLL) or chronic lymphocytic leukemia (CLL).
Why is venetoclax prescribed?
Adults with Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL), and Acute Myeloid Leukemia (AML) can take the prescription drug venetoclax is also known as Venclexta. Venetoclax works by slowing or stopping the growth of cancer cells.
Adult CLL patients who have undergone at least one prior therapy should be treated with venclyxto monotherapy if:
- In adult patients who are ineligible for or have tried unsuccessfully to use a B-cell receptor pathway inhibitor and have a 17p deletion or TP53 mutation; or
- In adult patients who have failed chemotherapy, immunotherapy, and a B-cell receptor pathway inhibitor but do not have a 17p deletion or TP53 mutation.
Adult patients newly diagnosed with acute myeloid leukemia (AML) who are ineligible for intensive chemotherapy may be treated with Venclyxto in combination with a hypomethylating agent or low-dose cytarabine. Get venetoclax in India at the best price from us, ARKON SOLUTIONS, through Name patient Import Services or Govt Hospital Supply.
Special Precautions For Disposal
- Exactly as prescribed by your doctor, take this medication. Never take it in more significant amounts, more frequently, or for a longer period of time than recommended by your doctor. Without first consulting, your doctor do not alter your dosage or stop taking this medication.
- A medication guide is included with this medication. Please carefully read and adhere to these guidelines. In case you have any questions, consult your doctor.
- Take this medication at the same time every day with food and water. Completely inhale the tablet. Do not chew, break, or crush it.
- Drink plenty of water daily to lessen the likelihood of a negative effect called tumor lysis syndrome.
- Starfruit, Seville oranges, and grapefruit-related products should not be consumed while taking this medication.
When shouldn’t you take venetoclax? (Contraindications)
- When you have a nasty infection.
- If a patient is breastfeeding or pregnant.
- If one has Hypersensitivity to any product ingredient.
List of excipients
Shelf life:Three years
Special storage precautions
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