Brand Name: Zerbaxa
Active Ingredient: Ceftolozane/tazobactam
Manufacturer Name: Merck Sharp & Dohme B.V.
Complicated Intra-abdominal Infections (cIAI), used in combination with metronidazole, in adult and pediatric patients (birth to less than 18 years old).
Complicated Urinary Tract Infections (cUTI), Including Pyelonephritis, in adult and pediatric patients (birth to less than 18 years old).
Hospital-acquired Bacterial Pneumonia and Ventilator-associated Bacterial Pneumonia (HABP/VABP), in adult patients 18 years and older.
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A monoclonal antibody in the treatment for lymphoma known as brentuximab vedotin reacts to a protein known as CD30 on some lymphoma cells. A cancer-fighting substance is also present, which could help eradicate cancerous cells. One example of an antibody-drug conjugate is brentuximab vedotin. One such monoclonal antibody is brentuximab. Monoclonal antibodies are more recent types of antibodies. In a lab, they are created. Targeting specific proteins on the cell surface, monoclonal antibodies look for cancer cells. Anaplastic large-cell lymphoma and Hodgkin lymphoma cells contain a protein called CD30, the target of the drug brentuximab. To deliver medicine to the cell, brentuximab adheres to the CD30 protein. After that, the medication kills the cell.
Patients with Hodgkin lymphoma benefit greatly from second-line treatment with benuximab vedotin and ESHAP. People with stage 3 or stage 4 Hodgkin lymphoma who have not previously received treatment and those who did not respond well to a stem cell transplant. Additionally, patients with systemic anaplastic large cell lymphoma did not respond to at least one prior multiple drug therapy. And those who did not react favourably to two distinct drug therapy regimens with various chemotherapeutic agents are all candidates for treatment with brentuximab. Each time you receive therapy, you can give the medication using a thin, short tube inserted into a vein in your arm.
Vedotin is delivered via Brentuximab to target CD30 + cancer cells and kill them specifically. Patients with CD30-positive lymphoma who received stem cell transplantation may see better results while taking the brentuximab vedotin. Some children and teenagers with Hodgkin lymphoma might not require radiation therapy at all, or it could reduce the need for it. In recent research, children and teenagers with a high-risk type of Hodgkin lymphoma were treated with the targeted drug brentuximab vedotin (Adcetris) instead of one chemotherapeutic drug. The trial used a well-known first- or first-line therapy strategy for high-risk juvenile Hodgkin cancer. When necessary, chemotherapy drug combinations are followed by radiation therapy.
Those who have a history of severe hypersensitivity to beta-lactam medications like ceftolozane/tazobactam, piperacillin/tazobactam, or others shouldn’t take zerbaxa.
After dilution with 0.9% sodium chloride or 5% dextrose, zerbaxa is stable for 24 hours when stored at ambient temperature and 7 days when refrigerated at 2 to 8°C (36 to 46°F). Never freeze a zerbaxa solution or diluted zerbaxa infusion.
Almost 85% of patients (288 of 340) who received zerbaxa had the illness successfully treated, as opposed to 75% (266 of 353) of patients who received levofloxacin, another antibiotic.
Zerbaxa should only be used to treat infections that are proven or strongly suspected to be caused by susceptible bacteria in order to avoid the development of drug-resistant bacteria and retain the efficacy of Zerbaxa and other antibacterial drugs.
For patients 18 years of age and older with CrCl more than 50 mL/min, Zerbaxa (ceftolozane/tazobactam) for Injection, 1.5 g (1 g/0.5 g) is prescribed.
Possible side effects include rashes, breathing issues, facial, lip, tongue, or throat swelling, severe stomach discomfort, bloody or watery diarrhoea, little to no urination, ankle or foot edoema, exhaustion, shortness of breath, unexpected numbness or weakness, and vision or speech issues.